:root {
  --bg: #06101d;
  --panel: #0d1c2c;
  --panel-2: #10263a;
  --text: #f1f8ff;
  --muted: #9bb1c5;
  --line: rgba(255,255,255,.11);
  --accent: #4de3b5;
  --accent-2: #6bb5ff;
  --danger: #ff6b7a;
  --warning: #ffd166;
  --shadow: 0 24px 70px rgba(0,0,0,.3);
}
* { box-sizing: border-box; }
body {
  margin: 0;
  color: var(--text);
  background:
    radial-gradient(circle at 10% 0%, rgba(77,227,181,.14), transparent 28rem),
    radial-gradient(circle at 90% 10%, rgba(107,181,255,.13), transparent 28rem),
    var(--bg);
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  min-height: 100vh;
}
button, input, select { font: inherit; }
button, .link-button { cursor: pointer; }
.hero {
  max-width: 1180px;
  margin: 0 auto;
  padding: 56px 24px 28px;
  display: flex;
  align-items: end;
  justify-content: space-between;
  gap: 24px;
}
.hero h1 { margin: 0; font-size: clamp(3rem, 9vw, 6.5rem); line-height: .9; letter-spacing: -.07em; }
.hero p { max-width: 650px; color: var(--muted); font-size: 1.05rem; }
.eyebrow { margin: 0 0 8px; color: var(--accent); letter-spacing: .16em; font-weight: 800; font-size: .76rem; }
.dna-mark { color: var(--accent); font-family: ui-monospace, monospace; font-size: clamp(1.2rem, 3vw, 2rem); letter-spacing: .28em; text-align: right; }
.dna-mark span { color: var(--accent-2); }
.tabs {
  position: sticky; top: 0; z-index: 10;
  display: flex; justify-content: center; gap: 8px;
  padding: 12px 20px; border-block: 1px solid var(--line);
  background: rgba(6,16,29,.86); backdrop-filter: blur(16px);
}
.tab, .secondary, .primary, .link-button {
  border-radius: 12px; border: 1px solid var(--line); padding: 11px 16px; color: var(--text); background: transparent; font-weight: 750;
}
.tab.active { background: var(--text); color: var(--bg); }
.primary { background: var(--accent); color: #032016; border-color: transparent; }
.primary:disabled { opacity: .35; cursor: not-allowed; }
.secondary:hover, .tab:hover, .link-button:hover { border-color: var(--accent); }
main { max-width: 1180px; margin: 0 auto; padding: 32px 24px 80px; }
.view { display: none; }
.view.active { display: block; animation: appear .25s ease-out; }
@keyframes appear { from { opacity: 0; transform: translateY(6px); } }
.section-heading { display: flex; justify-content: space-between; gap: 16px; align-items: end; margin-bottom: 20px; }
.section-heading h2, .section-heading h3 { margin: 0; }
.section-heading h2 { font-size: clamp(2rem, 5vw, 3.5rem); letter-spacing: -.04em; }
.section-heading.compact { align-items: center; }
.panel { background: linear-gradient(155deg, rgba(16,38,58,.96), rgba(10,25,40,.96)); border: 1px solid var(--line); border-radius: 22px; padding: 24px; box-shadow: var(--shadow); }
.lab-grid { display: grid; grid-template-columns: 1fr 1.2fr; gap: 18px; }
.panel h3 { margin: 0 0 20px; font-size: 1.25rem; }
.slots { display: grid; grid-template-columns: repeat(3, 1fr); gap: 12px; margin: 24px 0; }
.slot { aspect-ratio: 1.15; border-radius: 18px; border: 2px dashed var(--line); display: grid; place-items: center; font-size: clamp(2rem, 8vw, 4.4rem); font-weight: 900; background: rgba(255,255,255,.03); }
.slot.filled { border-style: solid; border-color: var(--accent); }
.base-buttons { display: grid; grid-template-columns: repeat(4, 1fr); gap: 10px; }
.base { min-height: 58px; border-radius: 14px; border: 0; color: #06101d; font-size: 1.3rem; font-weight: 900; }
.base[data-base="A"] { background: #6bb5ff; }
.base[data-base="C"] { background: #ffd166; }
.base[data-base="G"] { background: #ff8fab; }
.base[data-base="T"] { background: #4de3b5; }
.button-row { display: flex; gap: 10px; margin-top: 14px; }
.flow { display: grid; grid-template-columns: 1fr auto 1fr auto 1.3fr; align-items: center; gap: 12px; }
.flow div { padding: 16px; border: 1px solid var(--line); border-radius: 15px; min-width: 0; }
.flow span { display: block; color: var(--muted); font-size: .75rem; text-transform: uppercase; letter-spacing: .12em; }
.flow strong { display: block; margin-top: 8px; font-family: ui-monospace, monospace; font-size: 1.25rem; overflow-wrap: anywhere; }
.amino-card { margin: 18px 0; padding: 20px; border-radius: 16px; background: rgba(77,227,181,.09); border: 1px solid rgba(77,227,181,.25); }
.amino-card.empty { color: var(--muted); background: rgba(255,255,255,.03); border-color: var(--line); }
.amino-card h4 { margin: 0 0 6px; font-size: 1.4rem; }
.amino-card p { margin: 7px 0; color: var(--muted); }
.protein-panel { margin-top: 18px; }
.protein-chain { display: flex; gap: 10px; flex-wrap: wrap; min-height: 70px; align-items: center; }
.protein-chain.empty { color: var(--muted); }
.amino-token { width: 58px; height: 58px; border-radius: 50%; display: grid; place-items: center; background: var(--accent-2); color: #041526; font-weight: 900; position: relative; }
.amino-token:not(:last-child)::after { content: ""; position: absolute; left: 100%; width: 10px; height: 3px; background: var(--muted); }
.amino-token.stop { background: var(--danger); color: white; }
.sequence { color: var(--muted); font-family: ui-monospace, monospace; }
.game-layout { display: grid; grid-template-columns: 320px 1fr; gap: 18px; }
.setup-panel label { display: block; color: var(--muted); margin-bottom: 8px; }
select, input { width: 100%; color: var(--text); background: #071421; border: 1px solid var(--line); border-radius: 12px; padding: 12px 14px; }
.setup-panel .primary { width: 100%; margin-top: 12px; }
.hud { display: grid; grid-template-columns: 1fr 1fr; gap: 10px; margin-top: 24px; }
.hud div { border: 1px solid var(--line); border-radius: 14px; padding: 13px; }
.hud span { display: block; color: var(--muted); font-size: .75rem; }
.hud strong { display: block; font-size: 1.35rem; margin-top: 3px; }
.question-panel { min-height: 470px; }
.question-panel h3 { font-size: clamp(1.4rem, 4vw, 2.3rem); max-width: 760px; }
.question-visual { font-family: ui-monospace, monospace; font-size: clamp(2.6rem, 9vw, 6.5rem); font-weight: 900; letter-spacing: .12em; margin: 28px 0; overflow-wrap: anywhere; }
.answers { display: grid; grid-template-columns: 1fr 1fr; gap: 10px; }
.answer { padding: 15px; border-radius: 13px; border: 1px solid var(--line); color: var(--text); background: rgba(255,255,255,.035); font-weight: 750; text-align: left; }
.answer:hover:not(:disabled) { border-color: var(--accent-2); transform: translateY(-1px); }
.answer.correct { background: rgba(77,227,181,.2); border-color: var(--accent); }
.answer.wrong { background: rgba(255,107,122,.18); border-color: var(--danger); }
.feedback { min-height: 28px; font-weight: 700; }
.feedback.good { color: var(--accent); }
.feedback.bad { color: var(--danger); }
.hidden { display: none !important; }
.toolbar { display: grid; grid-template-columns: 1fr 260px; gap: 12px; margin-bottom: 18px; }
.card-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 14px; }
.info-card { border: 1px solid var(--line); border-radius: 18px; padding: 18px; background: rgba(13,28,44,.9); }
.info-card h3 { margin: 0 0 8px; }
.info-card p { color: var(--muted); margin: 7px 0; }
.badges { display: flex; flex-wrap: wrap; gap: 6px; margin-top: 12px; }
.badge { border-radius: 999px; padding: 5px 9px; background: rgba(107,181,255,.12); color: #b9dbff; font-size: .75rem; }
.link-button { text-decoration: none; display: inline-block; }
footer { border-top: 1px solid var(--line); color: var(--muted); text-align: center; padding: 24px; }
@media (max-width: 850px) {
  .hero { align-items: start; flex-direction: column; }
  .dna-mark { text-align: left; }
  .lab-grid, .game-layout { grid-template-columns: 1fr; }
  .card-grid { grid-template-columns: 1fr 1fr; }
}
@media (max-width: 560px) {
  .hero { padding-top: 34px; }
  .tabs { overflow-x: auto; justify-content: start; }
  main { padding-inline: 14px; }
  .panel { padding: 18px; border-radius: 18px; }
  .section-heading { align-items: start; flex-direction: column; }
  .flow { grid-template-columns: 1fr; }
  .flow > b { transform: rotate(90deg); text-align: center; }
  .answers, .toolbar, .card-grid { grid-template-columns: 1fr; }
  .base-buttons { grid-template-columns: repeat(2, 1fr); }
}

/* Taller de secuencias */
.sequence-layout {
  display: grid;
  grid-template-columns: minmax(0, 1.05fr) minmax(0, .95fr);
  gap: 1rem;
}

.sequence-input-panel textarea {
  width: 100%;
  margin-top: .55rem;
  resize: vertical;
  min-height: 11rem;
  padding: 1rem;
  border-radius: 14px;
  border: 1px solid var(--line);
  background: rgba(3, 12, 23, .72);
  color: var(--text);
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  font-size: 1rem;
  line-height: 1.55;
  letter-spacing: .08em;
  text-transform: uppercase;
}

.sequence-options {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: .8rem;
  margin: 1rem 0;
}

.sequence-options label {
  display: grid;
  gap: .4rem;
}

.sequence-options .checkbox-label {
  grid-column: 1 / -1;
  display: flex;
  align-items: center;
  gap: .55rem;
}

.checkbox-label input { width: auto; }

.stats-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: .75rem;
  margin: 1rem 0;
}

.stats-grid div {
  padding: .9rem;
  border: 1px solid var(--line);
  border-radius: 14px;
  background: rgba(255,255,255,.025);
}

.stats-grid span,
.stats-grid strong {
  display: block;
}

.stats-grid span { color: var(--muted); font-size: .82rem; }
.stats-grid strong { margin-top: .25rem; font-size: 1.2rem; }

.sequence-results {
  margin: 0;
}

.sequence-results dt {
  color: var(--muted);
  font-size: .8rem;
  text-transform: uppercase;
  letter-spacing: .08em;
  margin-top: .85rem;
}

.sequence-results dd {
  margin: .25rem 0 0;
  overflow-wrap: anywhere;
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  line-height: 1.55;
}

.translation-panel { margin-top: 1rem; }

.protein-output {
  min-height: 3rem;
  padding: 1rem;
  border-radius: 14px;
  background: rgba(3,12,23,.72);
  border: 1px solid var(--line);
  overflow-wrap: anywhere;
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  font-size: 1.12rem;
  letter-spacing: .12em;
}

.translation-grid {
  display: flex;
  flex-wrap: wrap;
  gap: .55rem;
  margin-top: 1rem;
}

.translation-token {
  min-width: 3.1rem;
  padding: .55rem .65rem;
  border: 1px solid var(--line);
  border-radius: 11px;
  text-align: center;
  background: rgba(255,255,255,.035);
}

.translation-token small,
.translation-token strong { display: block; }
.translation-token small { color: var(--muted); }
.translation-token strong { margin-top: .2rem; }
.translation-token.start { box-shadow: inset 0 0 0 1px rgba(95, 232, 183, .55); }
.translation-token.stop { box-shadow: inset 0 0 0 1px rgba(255, 120, 120, .62); }
.muted { color: var(--muted); }

@media (max-width: 760px) {
  .sequence-layout { grid-template-columns: 1fr; }
  .sequence-options { grid-template-columns: 1fr; }
}


.scientific-grid {
  margin-top: 1rem;
}
.scientific-grid .knowledge-card h3 {
  overflow-wrap: anywhere;
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
}
.scientific-grid code {
  display: block;
  margin-top: .65rem;
  overflow-wrap: anywhere;
}

/* Fronteras de investigación y genómica de sistemas */
.evidence-panel {
  margin-bottom: 1rem;
  border-color: rgba(255, 209, 102, .34);
  background: linear-gradient(155deg, rgba(55, 43, 18, .82), rgba(13, 28, 44, .96));
}
.research-toolbar {
  grid-template-columns: minmax(180px, .45fr) minmax(260px, 1fr);
  align-items: center;
}
.research-toolbar label { color: var(--muted); font-weight: 700; }
.frontier-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
.frontier-card { min-height: 100%; }
.frontier-card strong { color: var(--text); }
.source-line { font-size: .88rem; }
.research-heading { margin-top: 2.4rem; }
.research-workbench {
  display: grid;
  grid-template-columns: minmax(0, 1.05fr) minmax(0, .95fr);
  gap: 1rem;
  margin-bottom: 1rem;
}
.compact-workbench { grid-template-columns: .8fr 1.2fr; }
.research-input-panel textarea {
  width: 100%;
  min-height: 10rem;
  resize: vertical;
  padding: 1rem;
  border-radius: 14px;
  border: 1px solid var(--line);
  background: rgba(3, 12, 23, .72);
  color: var(--text);
  font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
  font-size: 1rem;
  line-height: 1.55;
  letter-spacing: .08em;
  text-transform: uppercase;
}
.variant-controls {
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: .75rem;
  margin-top: 1rem;
}
.variant-controls label {
  display: grid;
  gap: .4rem;
  color: var(--muted);
  font-size: .86rem;
}
.allele-controls { grid-template-columns: repeat(2, minmax(0, 1fr)); margin-bottom: 1rem; }
.research-result { overflow-wrap: anywhere; }
.result-callout {
  padding: 1rem;
  border: 1px solid rgba(77, 227, 181, .28);
  border-radius: 16px;
  background: rgba(77, 227, 181, .07);
}
.result-callout h3 { margin-bottom: .7rem; }
.warning-note {
  padding: .75rem;
  border-left: 3px solid var(--warning);
  background: rgba(255, 209, 102, .08);
  color: #ffe3a0;
  font-size: .9rem;
}
.panel-divider { border: 0; border-top: 1px solid var(--line); margin: 1.5rem 0; }
.mini-result {
  display: grid;
  gap: .3rem;
  padding: .7rem;
  margin: .55rem 0;
  border: 1px solid var(--line);
  border-radius: 12px;
  background: rgba(255,255,255,.025);
}
.mini-result code { overflow-wrap: anywhere; color: var(--accent); }
.mini-result small { color: var(--muted); }
.evidence-badge { margin-top: .5rem; display: inline-block; }

@media (max-width: 850px) {
  .frontier-grid, .research-workbench, .compact-workbench { grid-template-columns: 1fr; }
}
@media (max-width: 620px) {
  .research-toolbar, .variant-controls, .allele-controls { grid-template-columns: 1fr; }
}
#moduleRegistryGrid details { margin-top: .8rem; }
#moduleRegistryGrid code { display: inline-block; margin: .15rem .2rem .15rem 0; }
#organismProfileGrid .warning-note { margin-top: .75rem; }

/* --- Pulido de accesibilidad e interacción (v1.0) --- */
:focus-visible { outline: 2px solid var(--accent); outline-offset: 2px; border-radius: 10px; }
::selection { background: rgba(77, 227, 181, .28); color: var(--text); }
a { color: var(--accent-2); }
.tab, .secondary, .primary, .link-button, .answer, .base, .info-card {
  transition: border-color .18s ease, background .18s ease, transform .12s ease, box-shadow .18s ease, filter .18s ease;
}
.primary:hover:not(:disabled) { filter: brightness(1.06); transform: translateY(-1px); }
.secondary:hover, .tab:hover:not(.active), .link-button:hover { transform: translateY(-1px); }
.info-card:hover { border-color: var(--accent-2); transform: translateY(-2px); }
.slot.filled { box-shadow: 0 0 0 1px var(--accent), 0 8px 24px rgba(77, 227, 181, .12); }

/* Barra de desplazamiento acorde al tema */
* { scrollbar-color: rgba(107, 181, 255, .45) transparent; scrollbar-width: thin; }
*::-webkit-scrollbar { width: 10px; height: 10px; }
*::-webkit-scrollbar-thumb { background: rgba(107, 181, 255, .35); border-radius: 999px; }
*::-webkit-scrollbar-thumb:hover { background: rgba(107, 181, 255, .55); }

/* Respeta la preferencia de movimiento reducido */
@media (prefers-reduced-motion: reduce) {
  *, *::before, *::after {
    animation-duration: .001ms !important;
    animation-iteration-count: 1 !important;
    transition-duration: .001ms !important;
    scroll-behavior: auto !important;
  }
}